Name: Homocysteine support
SKU: 401-24
Availability: InStock

Product description

Homocysteine Support is a dietary supplement in capsule form containing betaine TMG, choline bitartrate, vitamin B2, vitamin B6 in two forms: pyridoxine and P5P, vitamin B9 Quatrefolic® as the active folate 5-MTHF, and vitamin B12 in three forms: hydroxocobalamin, methylcobalamin, and 5’deoxyadenosylcobalamin.

Anhydrous Betaine (TMG – trimethylglycine):

helps maintain normal homocysteine metabolism through participation in methylation processes,
supports proper functioning of the nervous system and cognitive functions,
supports liver function and detoxification processes,
participates in fat metabolism,
helps maintain proper cellular osmotic balance,
supports cellular energy production, which may contribute to reducing feelings of fatigue.

Choline:

choline is a key component of the product and plays an important role in many physiological processes; it is classified as a vitamin B-like substance,
choline participates in fat metabolism and transport from the liver,
choline is involved in homocysteine metabolism, an amino acid whose elevated levels may increase the risk of cardiovascular diseases.

Vitamin B2 (Riboflavin):

helps support proper functioning of the nervous system,
contributes to maintaining normal iron metabolism,
helps protect cells from oxidative stress,
contributes to normal energy metabolism,
helps maintain normal mucous membranes and healthy skin,
helps maintain normal vision,
helps maintain the normal condition of red blood cells,
contributes to the reduction of fatigue and tiredness.

Vitamin B9 Active Folate:

supports proper functioning of the nervous system,
supports normal psychological functions,
helps maintain concentration and learning ability,
supports proper memory and reasoning,
contributes to normal blood cell formation.

Quatrefolic®, the 4th generation of folate, is a registered trademark of Gnosis.

Vitamin B12:

helps support proper functioning of the nervous system,
helps maintain normal homocysteine metabolism,
helps maintain normal psychological functions,
helps support normal red blood cell formation,
supports proper functioning of the immune system,
contributes to reducing fatigue and tiredness,
plays a role in the process of cell division.

Methylcobalamin (MB-12): a biochemically active form of vitamin B12, extremely important in methylation processes. Absorption of vitamin B12 from food depends on good condition of the gastrointestinal tract, particularly the stomach.

Adenosylcobalamin (5′-deoxyadenosylcobalamin) / Adeno B-12: an active mitochondrial form of vitamin B12, directly involved in cellular energy production. It acts as a coenzyme in the conversion of methylmalonyl-CoA to succinyl-CoA, supporting amino acid and fatty acid metabolism. As a result, it supports proper mitochondrial function, as well as the nervous system and muscle function.

Hydroxocobalamin / Hydroxy B-12: a natural form of vitamin B12 with a high capacity for accumulation in the body. Due to its strong binding to transport proteins, it can be stored mainly in the liver and gradually released according to the body’s needs. It is converted into the biologically active forms of vitamin B12: methylcobalamin and adenosylcobalamin. This provides long-term and stable support for proper nervous system function, blood formation, and cellular metabolism.

L-Serine:

an endogenous amino acid, naturally occurring in the body,
participates in one-carbon metabolism, which is linked to homocysteine metabolism,
serves as a source of one-carbon units used in the folate cycle,
participates in the synthesis of other amino acids and biologically active compounds,
is a precursor of glycine, which functionally participates in pathways related to homocysteine.

Supplement facts

Ingredient	Amount per daily serving 1 capsule
Trimethylglycine (TMG)	150 mg	–
Vitamin B2 (riboflavin)	8 mg	571,4% DV*
Vitamin B6 (pyridoxal-5-phosphate)	2,5 mg	178,5% DV*
Vitamin B6 (pyridoxine hydrochloride)	2,5 mg	178,5% DV*
Vitamin B9 (6S)-5-methyltetrahydrofolic acid glucosamine salt – Quatrefolic®	300 µg	150% DV*
Vitamin B12 (5′-deoxyadenosylcobalamin)	30 µg	1200% DV*
Vitamin B12 (hydroxocobalamin)	40 µg	1600% DV*
Vitamin B12 (methylcobalamin)	30 µg	1200% DV*
Choline (choline bitartrate)	50 mg	–
L-serine	50 mg	–
Acacia fiber	23,5 mg	–
L-leucine	5 mg	–

*DV – Daily Value

Ingredients: Anhydrous Betaine (TMG – Trimethylglycine), Choline Bitartrate, Hydroxypropyl Methylcellulose – Vegetable Capsule Shell, L-Serine, 5′-Deoxyadenosylcobalamin, Acacia Fiber, Riboflavin, L-Leucine, Hydroxocobalamin, Pyridoxal-5-Phosphate, Pyridoxine Hydrochloride, Methylcobalamin, (6S)-5-Methyltetrahydrofolic Acid Glucosamine Salt (Quatrefolic®).

Gluten-free.

Servings per container: 90 capsules.

Suggested use

Take 1 capsule daily. Should be taken after a meal, no later than 4:00 p.m.

Do not exceed suggested use. Dietary supplements should not replace a varied diet. The product is recommended for adults. The product is suitable for vegans.

Warning: if pregnant or nursing, consult your doctor before use.

Capsule size: size “0” capsule, length 21 mm.

Keep away from the sun at a temperature below 25°C in the original packaging, out of reach of small children.

Production lot number / Best before – see the unit label (left side of the label).

Tests

Batch tests performed towards:

Microbiology: the presence of listeria, staphylococcus, Escherichia coli and coli groups, salmonella, total microbial count,
heavy metals (arsenic, cadmium, lead, mercury),
ethylene oxide and 2-chloroethanol,
gluten content.

The tests were carried out at the independent, accredited Laboratorium GBA Polska – Certificates of Accreditation no: AB 1095.

Support for homocysteine metabolism

Homocysteine is a sulfur-containing amino acid that is produced in the body as an intermediate product of methionine metabolism—an amino acid supplied through the diet. Under normal methylation processes, homocysteine does not accumulate in the body but is continuously converted into other compounds, primarily methionine. These mechanisms, however, require adequate availability of key nutrients.

Elevated homocysteine levels are considered a risk factor for the cardiovascular system, as they may negatively affect the vascular endothelium and contribute to impaired blood vessel function. Excessively high homocysteine concentrations are also associated with impaired nervous system function, cognitive processes, and increased oxidative stress.

Homocysteine is closely linked to methylation processes, which are essential for proper cellular function, neurotransmitter synthesis, regulation of gene expression, and detoxification. Elevated homocysteine levels may indicate reduced efficiency of these processes.

Maintaining normal homocysteine levels is an important element of preventive healthcare. Proper homocysteine levels support not only the heart and blood vessels, but also the nervous system, cellular metabolism, and overall biochemical balance of the body.

Elevated homocysteine levels most commonly result from disturbances in methylation processes—biochemical mechanisms responsible for converting homocysteine into other compounds that are safe for the body. For these processes to function properly, an adequate supply of specific nutrients is required, particularly vitamin B12, choline, and betaine (TMG). Deficiencies in these nutrients may lead to the accumulation of homocysteine in the blood.

Dietary factors also play a significant role. Insufficient intake of foods rich in B vitamins, high-quality protein, and natural sources of choline may impair homocysteine metabolism. This is especially relevant in the case of elimination diets, low-protein diets, or diets low in animal-derived products.

In a formulation aimed at supporting the maintenance of normal homocysteine levels, the efficiency and continuity of methylation processes are of key importance. The use of three forms of vitamin B-12 allows for comprehensive support of homocysteine metabolism and better alignment of the supplement’s action with the body’s physiological needs.

Methylcobalamin plays a direct role in the remethylation of homocysteine to methionine. As a biologically active form of vitamin B-12, it participates in key methylation reactions that are essential for maintaining normal homocysteine levels.

Hydroxocobalamin, as a natural and storage-capable form of vitamin B-12, provides long-term and stable support for the body. Thanks to its ability to convert into active B-12 forms, it helps ensure a continuous availability of the vitamin necessary for proper homocysteine metabolism.

Adenosylcobalamin supports mitochondrial function and cellular energy production, which indirectly influences the efficiency of metabolic processes, including methylation.

The combination of three forms of vitamin B-12 enables multidirectional, physiological support for the regulation of homocysteine levels, while also supporting the nervous system, energy metabolism, and overall metabolic balance of the body.

Vitamins B9 and B2 play key, complementary roles in methylation processes. Their presence increases the effectiveness of the formula and supports the body’s physiological mechanisms regulating homocysteine levels.

Vitamin B9 (active folate) plays a direct role in the remethylation of homocysteine to methionine. It participates in the folate cycle, which is responsible for the proper transfer of one-carbon units required to reduce homocysteine levels and maintain the body’s metabolic balance.

Vitamin B2 (riboflavin) acts as an essential cofactor for enzymes involved in the folate cycle. It supports the activation and efficient utilisation of vitamin B9, thereby indirectly influencing the efficiency of methylation processes.

The presence of vitamin B2 improves the performance of the entire methylation pathway, enhancing the effectiveness of actions aimed at regulating homocysteine levels.

The combination of vitamins B9 and B2 provides coherent and systemic support for homocysteine metabolism, while also supporting cell division processes, nervous system function, and overall metabolic balance of the body.

Choline and betaine (TMG) are included in the formulation due to their key role as methyl group donors in homocysteine metabolism. Both ingredients support an alternative, folate-independent remethylation pathway of homocysteine, which increases the effectiveness and flexibility of the formula.

Choline, after being converted into betaine (TMG), participates in the enzymatic remethylation of homocysteine to methionine. In this way, it supports the maintenance of normal homocysteine levels, particularly in situations of increased demand for methyl groups or reduced efficiency of other methylation pathways.

Betaine (TMG) acts as a direct methyl group donor and plays a central role in lowering homocysteine levels through the activation of betaine–homocysteine methyltransferase (BHMT). This mechanism is especially important in the liver, where a significant proportion of homocysteine metabolism takes place.

Choline also supports normal liver function and fat metabolism, which is important for overall metabolic balance and the efficiency of methylation processes.

The combination of choline and betaine (TMG) provides comprehensive support for homocysteine regulation, complementing the action of B vitamins and enhancing the overall effectiveness of the formula.