Supplementation with Magtein® (magnesium L-threonate) increases magnesium levels in the brain, which contributes to improved learning ability, working memory, as well as short-term and long-term memory.

A clinical study conducted by Liu et al. (2016) showed that 12 weeks of Magtein® supplementation led to increased synapse density and enhanced cognitive function in older adults. This effect is attributed to improved synaptic plasticity in the hippocampus – a key brain region for learning and memory processes.

Liu G, Weinger JG, Lu ZL, Xue F, Sadeghpour S. “Efficacy and Safety of MMFS-01, a Synapse Density Enhancer, for Treating Cognitive Impairment in Older Adults: A Randomized, Double-Blind, Placebo-Controlled Trial.” J Alzheimer’s Dis. 2016;49:971-990.

Yes, Magtein® has been shown to help reduce stress and anxiety.

In a clinical study by Hewlings & Kalman (2022) conducted on individuals aged 50–70, 12 weeks of supplementation significantly reduced anxiety and stress levels on the Hamilton Anxiety Rating Scale (HAM-A) compared to placebo. This effect is linked to magnesium’s influence on neurotransmitters, such as serotonin and dopamine, and its role in regulating the HPA axis – the body’s central stress response system.

The HPA axis (hypothalamus–pituitary–adrenal) is the main system responsible for managing the body’s response to stress.

In a stressful situation, the hypothalamus releases CRH (corticotropin-releasing hormone), which stimulates the pituitary gland to produce ACTH (adrenocorticotropic hormone). ACTH then signals the adrenal glands to release cortisol – the stress hormone. Cortisol helps the body manage threats by increasing blood glucose, blood pressure, and suppressing inflammation. However, chronic stress can overload the HPA axis, leading to dysregulation, which may manifest as fatigue, sleep disturbances, weakened immunity, or mood disorders.

Magnesium deficiency can contribute to overactivation of the HPA axis, exacerbating these effects.

Hewlings SJ, Kalman DS. “A Randomized, Double-Blind, Placebo-Controlled, Comparator Trial Evaluating Magtein® Magnesium Supplement on Quality of Life as Related to Levels of Stress, Anxiety, Fear and Other Indicators.” EC Nutrition 17.3 (2022): 07-14.

Studies have shown that Magtein® supplementation improves sleep quality and daytime functioning.

In a study by Hausenblas et al. (2024), participants taking Magtein® experienced better sleep quality, fewer night-time awakenings, and a greater sense of recovery during the day. This effect is due to the modulation of neurotransmitter activity.

Magnesium inhibits the excessive activation of NMDA (glutamate) receptors, which helps reduce neural excitation. At the same time, it supports the activity of GABA, the brain’s primary inhibitory neurotransmitter, which is essential for calmness, relaxation, and falling asleep.

Hausenblas H, Lynch T, Hooper S, Shrestha A, Rosendale D, Gu J. “Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: A randomized controlled trial.” Sleep Medicine: X. August 17, 2024.

Studies have shown that Magtein® has a beneficial effect on cognitive functions across different age groups.

In a study by Zhang et al. (2022) involving 109 healthy adults, participants experienced improvements in memory retention and information processing speed. While positive effects were observed in all participants, the greatest benefits were seen in older adults.

This may be due to the natural decline in brain magnesium levels with age, making older individuals more responsive to the effects of supplementation. At the same time, early magnesium supplementation may have a preventive effect, helping to maintain optimal magnesium levels in the brain and slow down the cognitive decline associated with aging.

Zhang C, Hu Q, Li S, Dai F, Qian W, Hewlings S, Yan T, Wang Y. “A Magtein, Magnesium L-Threonate, -Based Formula Improves Brain Cognitive Functions in Healthy Chinese Adults.” Nutrients. 2022; 14(24):5235.